Journal
LANGMUIR
Volume 26, Issue 17, Pages 13760-13762Publisher
AMER CHEMICAL SOC
DOI: 10.1021/la1023554
Keywords
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Funding
- EPSRC
- Royal Society
- University of Southampton (NanoUSRG)
- Research Council U.K. (RCUK)
- Engineering and Physical Sciences Research Council [EP/F009186/1, EP/F056826/1] Funding Source: researchfish
- EPSRC [EP/F009186/1, EP/F056826/1] Funding Source: UKRI
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We present a novel nanoparticle building block system based on the interactions between short synthetic oligonucleotides and peptides. Gold nanoparticles coated with DNA-binding peptides can be attached to self-organized oligonucleotide templates to formulate well-ordered structures of nanoparticles. By regulating the amount of DNA-binding peptide attached to the nanoparticle surface and using specifically designed oligonucleotides, the nanoparticle assembly can be controlled to form dimers, trimers, and adjustable-length nanoparticle chains as well as more complex structures.
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