Journal
LANGMUIR
Volume 26, Issue 22, Pages 16884-16889Publisher
AMER CHEMICAL SOC
DOI: 10.1021/la103095d
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Using a short-chain zwitterionic organosiloxane, silica nanoparticles were stabilized against aggregation by high ionic strength and/or proteins. Turbidimetry and dynamic light scattering showed that zwitterated nanoparticles did not exhibit a significant increase in hydrodynamic radius. When challenged with 3 M NaCl or 50% fetal bovine serum, aggregation was inhibited for at least 24 It, longer with mild heat treatment, which produced nanoparticles with zero net surface charge. These findings suggest zwitteration of silica-capped nanoparticles provides excellent stability for in vivo circulation diagnostics and therapies.
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