Journal
LANGMUIR
Volume 26, Issue 20, Pages 16025-16030Publisher
AMER CHEMICAL SOC
DOI: 10.1021/la1023746
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Funding
- French National Research Agency, ANR-PCV Prob-DOM
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This work combined two tools, giant unilamellar vesicles (GUVs) and core-shell magnetic nanoparticles (CSMNs), to develop a simplified model for studying interactions between the cell membrane and nanoparticles. We focused on charged functionalized CSMNs that can be either cationic or anionic. Using optical, electron, and confocal microscopy, we found that giant vesicle-nanoparticle interactions did not result from a simple electrostatic phenomenon because cationic CSMNs tended to bind to positively charged bilayers, whereas anionic CSMNs remained inert.
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