Journal
LANGMUIR
Volume 26, Issue 12, Pages 9885-9890Publisher
AMER CHEMICAL SOC
DOI: 10.1021/la100226u
Keywords
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Funding
- Hellman Family Faculty Fund
- Nanoscience and Nanotechnology Institute at the University of California, Berkeley
- Lawrence Berkeley National Laboratory
- Korean Government (MOEHRD) [KRF-2006352-D00048]
- National Science Foundation
- National Research Foundation of Korea [2006-352-D00048] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Designing biomimetic matrices with precisely controlled structural organization that provides biochemical and physical cues to regulate cell behavior is critical for the development of tissue-regenerating materials. We have developed novel liquid-crystalline film matrices made from genetically engineered M13 bacteriophages (viruses) that exhibit the ability to control and guide cell behavior for tissue-regenerating applications. To facilitate adhesion between the viruses and cells, 2700 copies of the M 13 major coat protein were genetically engineered to display integrin-binding peptides (RGD). The resulting nanofiber-like viruses displaying RGD motifs were biocompatible with neuronal cells and could be self-assembled to form long-range-ordered liquid-crystalline matrices by a simple shearing method. The resulting aligned structures were able to dictate the direction of cell growth. Future use of these virus-based materials for regenerating target tissues in viva would provide great opportunities for various tissue therapies.
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