Journal
LANGMUIR
Volume 25, Issue 21, Pages 12522-12528Publisher
AMER CHEMICAL SOC
DOI: 10.1021/la901776a
Keywords
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Funding
- National Natural Science Foundation of China [20474032, 20774051, 20904025]
- Outstanding Youth Fund [50625310]
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Poly(ethylene glycol)-b/ock-poly(acrylic acid-co-acrylamidophenylboronic acid) [PEG(114)-b-(PAA(63)-co-PAAPBA(107))] was synthesized by the modification of poly(ethylene glycol)-block-poly(acrylic acid) (PEG(114)-b-PAA(170)) with 3-aminophenyl-boronic acid (APBA). Glucose-responsive PEG(114)-b-(PAA(63)-co-PAAPBA(107)) self-assembled into core-shell micelles with the hydrophobic core composed of PAAPBA and hydrophilic shell composed of PEG in aqueous solution. The swelling and disaggregating behaviors of micelles responding to glucose were investigated by using light scattering in aqueous solution at pH 7.4. Characterization of insulin-loaded micelles and their drug release in solutions with various glucose concentrations were further studied. The results demonstrated that the drug release rate can be controlled by variation of glucose concentration.
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