Journal
LANGMUIR
Volume 25, Issue 18, Pages 11082-11089Publisher
AMER CHEMICAL SOC
DOI: 10.1021/la901413n
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Funding
- Royal Society/Wolfson Research Merit Award
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Two series of poly(ethylene oxide)-tetrapeptide conjugates have been prepared using a Click reaction between an alkyne-modified tetra(phenylalanine) or tetra(valine) and various azide-terminated poly(ethylene oxide) (PEO) oligomers. Three different PEO precursors were used to prepare these conjugates, with number-average molecular weights of 350, 1200, and 1800 Da. Assembly of mPEO-F-4-OEt and mPEO-V-4-OEt conjugates was achieved by dialysis of a THF solution of the conjugate against water or by direct aqueous rehydration of a thin film. The PEO length has a profound effect on the outcome of the self-assembly, with the F-4 conjugates giving rise to nanotubes, fibers, and wormlike micelles, respectively, as the length of the PEO block is increased. For the V-4 series. die propensity to form beta-sheets dominates, and hence, the self-assembled structures are reminiscent of those formed by peptides alone, even at the longer PEO lengths. Thus, this systematic Study demonstrates that the self-assembly of PEO-peptides depends on both the nature of the peptides and the relative PEO block length.
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