Self-Organization of Synthetic Cholesteryl Oligoethyleneglycol Glycosides in Water

Lectin-sugar recognition systems, are of interest in the pharmaceutical field, especially for the development of drug carriers, tailored for selective delivery. This paper deals with the anhydrous and aqueous self-organization properties of a synthetic cholesteryl oligoethyleneglycol glycoside with the aim of their incorporation in liposomes. Successive phases (lamellar, R3m, lm3m, micelles) have been described depending on water content and temperature. As a result of the presence of sugar residues and their hydration ability, this glycolipid shows a large range of packing parameter with increasing water content. However, because of oligoethlyleneglycol spacer, a slight dehydration has been observed with increasing temperature from 20 to 60 degrees C.