Journal
LANGMUIR
Volume 25, Issue 17, Pages 9734-9740Publisher
AMER CHEMICAL SOC
DOI: 10.1021/la901092x
Keywords
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Funding
- Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan [20034055]
- Kansai University
- Grants-in-Aid for Scientific Research [20034055] Funding Source: KAKEN
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Biodegradable copolymers consisting of a hydrophilic poly[L-aspartic acid-alt-poly(ethylene glycol)] (poly(L-Asp-alt-PEG)) backbone and hydrophobic capryl units as side chains were synthesized. The amphiphilic copolymer wits found to form nanosized hydrogel particles (nanogels) of approximately 15 nm in size by self-assembly at 20 degrees C in aqueous media, and the nanogel solutions displayed phase-transition in response to temperature. The transition of the nanogel solution wits reversible and tunable in the range from 19 to 55 degrees C by variation of the amounts of capryl units introduced and the solution concentration. The nanogels were gradually degraded within days in a phosphate buffer solution (PBS) at 37 degrees C. Temperature-responsive biodegradable nanogel systems consisting of biocompatible PEG may have potential utility for high biocompatibility temperature-responsive nanodevices such as microreactor systems, molecular-chaperones, and drug delivery vehicles.
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