Journal
LANGMUIR
Volume 24, Issue 17, Pages 9211-9214Publisher
AMER CHEMICAL SOC
DOI: 10.1021/la801487f
Keywords
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Funding
- Nanotechnology
- National Science Foundation [DMR-0705907]
- China Scholarship Council
- Office of Naval Research [N000140410409]
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In this work, we investigate protein adsorption from single protein Solutions and complex media such as 100% blood serum and plasma onto poly(sulfobetaine methacrylate) (polySBMA)-grafted surfaces via atom transfer radical polymerization (ATRP) at varying film thicknesses. It is interesting to observe that protein adsorption exhibits a minimum at a medium film thickness. Results show that the surface with 62 run polySBMA brushes presents the best nonfolding character in 100% blood serum and plasma although all of these surfaces are highly resistant to nonspecific protein adsorption from single fibrinogen and lysozyme solutions. Surface resistance to 100% blood serum or plasma is necessary for many applications from blood-contacting devices to drug delivery. This work provides a new in vitro evaluation standard for the application of biomaterials in vivo.
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