Journal
LANGMUIR
Volume 24, Issue 7, Pages 3417-3421Publisher
AMER CHEMICAL SOC
DOI: 10.1021/la701688t
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Novel hollow silica nanoparticles (HSNPs) for drug delivery vehicles were synthesized using silica-coated magnetic assemblies, which are composed of a number of Fe3O4 nanocrystals, as templates. The core cavity was obtained by removal of Fe3O4 phase with hydrochloric acid and subsequent calcination at a high temperature. HSNPs were modified by amine in order to introduce positive surface charge and further PEGylated for increased solubility in aqueous medium. Doxorubicin as a model drug was loaded into the HSNPs, and notable sustained drug release from HSNPs was demonstrated.
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