Journal
LANGMUIR
Volume 24, Issue 17, Pages 9237-9240Publisher
AMER CHEMICAL SOC
DOI: 10.1021/la802208v
Keywords
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Funding
- Carolina Center for Cancer Nanotechnology Excellence
- NCI
- Burroughs Wellcome Foundation
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An expedient and inexpensive method to generate patterned aldehydes on self-assembled monolayers (SAMs) of alkanethiolates on gold with control of density for subsequent chemoselective immobilization from commercially available starting materials has been developed. Utilizing microfluidic cassettes, primary alcohol oxidation of tetra(ethylene glycol) undecane thiol and 11-mercapto-1-undecanol SAMs was performed directly on the surface generating patterned aldehyde groups with pyridinium chlorochromate. The precise density of surface aldehydes generated can be controlled and characterized by electrochemistry. For biological applications, fibroblast cells were seeded on patterned surfaces presenting biospecifc cell adhesive (Arg-Glyc-Asp) RGD peptides.
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