Journal
LANGENBECKS ARCHIVES OF SURGERY
Volume 394, Issue 5, Pages 837-842Publisher
SPRINGER
DOI: 10.1007/s00423-009-0497-5
Keywords
Thyroidectomy; Hemorrhagic complication; FloSeal; Tabotamp; Hemostatic agent
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The objective of this study was to compare the effectiveness of FloSealA (R) matrix hemostatic agent with hemostatic surgical procedures and TabotampA (R) in thyroid surgery. One hundred fifty-five consecutive total thyroidectomy patients were recruited at our institution between January 2005 and December 2007. Exclusion criteria were applied. Patients were randomized to one of three hemostatic approaches: 49 received surgical procedures only, and 52 received oxidized regenerated cellulose patch (Tabotamp Fibrillar 2.5 x 5 cm) and 54 FloSeal (5,000 U/5 mL). The same surgeon performed all operations. Mean operating time was reduced in the FloSeal group (105 min) vs. surgical (133 min, p = 0.02) and vs. Tabotamp (122 min, p = 0.0003). Also, wound drain removal occurred earlier with FloSeal (p = 0.006 vs. surgical; p = 0.008 vs. Tabotamp) resulting in shorter postoperative hospital stay in the FloSeal group (p = 0.02 vs. surgical; p = 0.002 vs. Tabotamp). FloSeal matrix is an effective additional agent to conventional haemostatic procedures in thyroid surgery.
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