Journal
QUALITY OF LIFE RESEARCH
Volume 25, Issue 6, Pages 1423-1432Publisher
SPRINGER
DOI: 10.1007/s11136-015-1171-8
Keywords
Europe; General population; Osteoarthritis; Self-rated health
Categories
Funding
- European Union [2005121]
- Ministry of Science, Baden-Wurttemberg
- Dutch Ministry of Health, Welfare and Sports
- National Fund for Health Research (Fondo de Investigaciones en Salud) of Spain [FIS PI 05/1898, FIS RETICEF RD06/0013/1013, FIS PS09/02143]
- Swedish Ministry of Higher Education
- Medical Research Council of Great Britain
- Arthritis Research UK
- British Heart Foundation
- International Osteoporosis Foundation
- MRC [MC_U147585819, MC_U147585827] Funding Source: UKRI
- Medical Research Council [MC_U147585819, MC_UU_12011/1, MC_U147585824, MC_U147585827, MC_UP_A620_1014, U1475000001] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0508-10082, NF-SI-0513-10085, CL-2006-18-006, CL-2014-26-001] Funding Source: researchfish
- Versus Arthritis [19583] Funding Source: researchfish
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Osteoarthritis (OA) has been shown to be associated with decreased physical function, which may impact upon a person's self-rated health (SRH). Only a few studies have examined the association between OA and SRH in the general population, but to date none have used a clinical definition of OA. The objectives are: (1) To examine the cross-sectional association between clinical OA and fair-to-poor SRH in the general population; (2) To examine whether this association differs between countries; (3) To examine whether physical function is a mediator in the association between clinical OA and SRH. Baseline data of the European Project on OSteoArthritis (EPOSA) were used, which includes pre-harmonized data from six European cohort studies (n = 2709). Clinical OA was defined according to the American College of Rheumatology criteria. SRH was assessed using one question: How is your health in general? Physical function was assessed using the Western Ontario and McMaster Universities OA Index and Australian/Canadian OA Hand Index. The prevalence of fair-to-poor SRH ranged from 19.8 % in the United Kingdom to 63.5 % in Italy. Although country differences in the strength of the associations were observed, clinical OA of the hip, knee and hand were significantly associated with fair-to-poor SRH in five out of six European countries. In most countries and at most sites, the association between clinical OA and fair-to-poor SRH was partly or fully mediated by physical function. Clinical OA at different sites was related to fair-to-poor SRH in the general population. Most associations were (partly) mediated by physical functioning, indicating that deteriorating physical function in patients with OA should be a point of attention in patient care.
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