Journal
APPLIED SPECTROSCOPY REVIEWS
Volume 50, Issue 5, Pages 387-406Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/05704928.2014.999936
Keywords
Raman spectroscopy; fluorescence suppression; time-domain optical methods; frequency-domain optical methods; wavelength-domain optical methods; computational methods for fluorescence background removal
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Funding
- Agency for Science Technology and Research, Science and Engineering Research Council in Singapore [122-PSF-0012, 102 167 0115]
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Raman spectroscopy is an important and powerful technique for analyzing the chemical composition of biological or nonbiological samples in many fields. A serious challenge frequently encountered in Raman measurements arises from the existence of the concurrent fluorescence background. The fluorescence intensity is normally several orders of magnitude larger than the Raman scattering signal, especially in biological samples. Such fluorescence background must be suppressed in order to obtain accurate Raman spectra. Several different techniques have been explored for this purpose. These techniques could be generally grouped into time-domain, frequency-domain, wavelength-domain, and computational methods in addition to various Raman enhancement techniques and other unconventional methods. This review briefly describes the fundamental principles of each group of methods, reports the most recent advances, and makes comparison across those major categories of techniques in terms of cost and performance in a hope to guide interested readers to select proper methods for specific applications.
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