Journal
LANCET ONCOLOGY
Volume 9, Issue 11, Pages 1108-1111Publisher
LANCET LTD
DOI: 10.1016/S1470-2045(08)70281-X
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Funding
- US National Cancer Institute [R01 CA099471]
- US National Institutes of Health
- US Department of Defense [W81XWH-06-1-0095]
- Marsha Rivkin Ovarian Cancer Research Foundation (Seattle, WA, USA)
- Department of Defense Ovarian Concept Award [W81XWH-07-1-0303]
- Teal Ribbon Ovarian Cancer Research Foundation (Philadelphia, PA, USA)
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The association between ovarian cancer risk and reproductive factors has been well established, and two main theories, incessant ovulation and gonadotropin stimulation, have been proposed to explain the mechanism. Recent studies using animal models of ovarian tumorigenesis, and analysis of ovarian tissues from prophylactic oophorectomies, suggest that depletion of ovarian follicles might underlie the epidemiological findings linking reproductive history and ovarian cancer risk.
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