Journal
LANCET NEUROLOGY
Volume 12, Issue 8, Pages 822-838Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/S1474-4422(13)70124-8
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Funding
- Centre of Excellence in Neurodegeneration (COEN) concordat (UK Medical Research Council) [COEN017]
- Centre of Excellence in Neurodegeneration (COEN) concordat (German Centre for Neurodegenerative Disease [DZNE]) [COEN017]
- Centre of Excellence in Neurodegeneration (COEN) concordat (Canadian Institutes of Health Research [CIHR]) [COEN017]
- Royal Society of Edinburgh
- Scottish Imaging Network, a Platform for Scientific Excellence (SINAPSE) Collaboration
- UK Cross-Council Centre for Cognitive Ageing and Cognitive Epidemiology, Edinburgh, UK
- Carl Friedrich von Siemens Foundation
- Vascular Dementia Research Foundation
- NIHR Biomedical Research Unit in Dementia
- FP6 ERA-NET NEURON grant [01 EW1207]
- Canadian Stroke Network
- MRC [MR/J006971/1, G0601846] Funding Source: UKRI
- Medical Research Council [MR/J006971/1, G0601846] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0611-10084, NF-SI-0508-10123] Funding Source: researchfish
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS017950] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [K23AG028726] Funding Source: NIH RePORTER
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Cerebral small vessel disease (SVD) is a common accompaniment of ageing. Features seen on neuroimaging include recent small subcortical infarcts, lacunes, white matter hyperintensities, perivascular spaces, microbleeds, and brain atrophy. SVD can present as a stroke or cognitive decline, or can have few or no symptoms. SVD frequently coexists with neurodegenerative disease, and can exacerbate cognitive deficits, physical disabilities, and other symptoms of neurodegeneration. Terminology and definitions for imaging the features of SVD vary widely, which is also true for protocols for image acquisition and image analysis. This lack of consistency hampers progress in identifying the contribution of SVD to the pathophysiology and clinical features of common neurodegenerative diseases. We are an international working group from the Centres of Excellence in Neurodegeneration. We completed a structured process to develop definitions and imaging standards for markers and consequences of SVD. We aimed to achieve the following: first, to provide a common advisory about terms and definitions for features visible on MRI; second, to suggest minimum standards for image acquisition and analysis; third, to agree on standards for scientific reporting of changes related to SVD on neuroimaging; and fourth, to review emerging imaging methods for detection and quantification of preclinical manifestations of SVD. Our findings and recommendations apply to research studies, and can be used in the clinical setting to standardise image interpretation, acquisition, and reporting. This Position Paper summarises the main outcomes of this international effort to provide the STandards for Reporting Vascular changes on nEuroimaging (STRIVE).
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