Journal
LANCET NEUROLOGY
Volume 11, Issue 7, Pages 605-617Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/S1474-4422(12)70098-4
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Funding
- Johns Hopkins National Institute for Mental Health Research Center [P30MH075673]
- Whitehurst foundation gift
- Johns Hopkins University T32 Training Program in Hematology
- John Hopkins University Project RESTORE and Multiple Sclerosis Center
- American Academy of Neurology Practice Research Fellowship grant
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Survival in people infected with HIV has improved because of an increasingly powerful array of antiretroviral treatments, but neurological symptoms due to comorbid conditions, including infection with hepatitis C virus, malnutrition, and the effects of accelerated cardiovascular disease and ageing, are increasingly salient. A therapeutic gap seems to exist between the salutary effects of antiretroviral regimens and the normalisation of neurological function in HIV-associated neurocognitive disorders. Despite the advances in antiretroviral therapy, CNS opportunistic infections remain a serious burden worldwide. Most opportunistic infections can be recognised by a combination of characteristic clinical and radiological features and are treatable, but some important challenges remain in the diagnosis and management of HIV-associated opportunistic infections.
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