Journal
LANCET NEUROLOGY
Volume 9, Issue 12, Pages 1214-1227Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/S1474-4422(10)70220-9
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Neurological complications of systemic cancer those arising outside the nervous system can be distressing disabling, and sometimes fatal Diagnosis is often difficult because different neurological disorders may present with similar signs and symptoms Furthermore comorbid neurological illnesses, common in elderly patients with cancer, can complicate diagnosis Early diagnosis and aggressive treatment can improve neurological symptoms and can substantially enhance a patient s quality of life We approach the problem of neurological complications of systemic cancer as would a neurologist first by identifying the anatomical area or areas that are affected (ie, brain spinal cord peripheral nerve), then by evaluating the diagnostic approach considering the symptoms and signs and including appropriate laboratory tests, and finally by recommending treatment We focus on disorders that are difficult to diagnose need neurological consultation and for which effective treatments exist
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