Journal
LANCET INFECTIOUS DISEASES
Volume 13, Issue 4, Pages 362-372Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S1473-3099(13)70034-3
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Funding
- European and Developing Countries Clinical Trials Partnership (EDCTP), Netherlands
- EDCTP
- TB-NEAT
- UK Medical Research Council
- UBS Optimus Foundation, Switzerland
- University College London Hospitals (UCLH) Comprehensive Biomedical Research Centre
- NIH Intramural Research Program
- UCLH National Health Service Foundation Trust
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Biomarkers are indispensable to the development of new tuberculosis therapeutics and vaccines. The most robust biomarkers measure factors that are essential to the underlying pathological process of the disease being treated, and thus can capture the full effects of many types of interventions on clinical outcomes in multiple prospective, randomised clinical trials. Many Mycobacterium tuberculosis and human biomarkers have been studied over the past decade. Present research focuses on three areas: biomarkers predicting treatment efficacy and cure of active tuberculosis, the reactivation of latent tuberculosis infection, and the induction of protective immune responses by vaccination. Many older, non-specific markers of inflammation, when considered in isolation, do not have sufficient predictive values for clinical use in tuberculosis. Although no new accurate, tuberculosis-specific biomarkers have yet been discovered, substantial progress has been made in some areas. However, the qualification of biomarkers as a surrogate for a clinical endpoint in tuberculosis is very challenging, and, for biomarkers that are non-culture-based, impossible to pursue without the availability of well characterised biobanks containing biospecimens from patients who have had adequate follow-up to establish long-term treatment outcome. We review progress in tuberculosis biomarker development and efforts being made to harness resources to meet future challenges.
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