Journal
LANCET INFECTIOUS DISEASES
Volume 12, Issue 4, Pages 330-340Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S1473-3099(11)70341-3
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Funding
- Walloon Region
- GlaxoSmithKline Biologicals, Belgium
- biomedical sciences career award from Burroughs Wellcome Fund
- Canadian Institutes of Health Research
- SickKids Foundation
- Child and Family Research Institute (BC, Canada)
- Women and Children's Health Research Institute (AL, Canada)
- Manitoba Institute of Child Health
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Chronic infections during pregnancy are highly prevalent in some parts of the world. Infections with helminths, Trypanosoma cruzi, Plasmodium spp, and HIV might affect the development of fetal immunity and susceptibility to postnatal infections independently of in-utero transmission of the pathogens. Fetal adaptive immune responses are common in neonates who have been exposed to maternal infection during pregnancy but not infected themselves. Such responses could affect the development of immunity to the homologous pathogens and their control during the first few years of life. Fetal innate and regulatory responses might also affect immunity to unrelated pathogens and responses to vaccines. Strategies to improve child health should integrate the possible clinical implications of in-utero exposure to chronic maternal infections.
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