Journal
LANCET
Volume 384, Issue 9956, Pages 1789-1799Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/S0140-6736(14)61278-2
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Funding
- Chief Investigator of a National Institute for Health Research (NIHR) Programme [RP-RP-DG-1108-10012]
- NIHR
- Tommy's baby
- NIHR Mental Health Biomedical Research Centre at the South London
- Maudsley NHS Foundation Trust and King's College London
- Wellcome Trust
- British Occupational Health Research Foundation
- National Institute of Social Care Research and Health Research
- Big Lottery
- Medical Research Council (MRC)
- Women's Mental Health Trust
- National Alliance for Research on Schizophrenia and Depression (NARSAD)
- Medical Research Foundation for research in post-partum psychosis
- Indian Council of Medical Research
- Ranbaxy India
- Medical Research Council [MR/L010305/1] Funding Source: researchfish
- Medical Research Foundation [C0439] Funding Source: researchfish
- National Institutes of Health Research (NIHR) [RP-DG-1108-10012] Funding Source: National Institutes of Health Research (NIHR)
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The perinatal period is associated with an increased risk of severe mental disorders. We summarise the evidence regarding the epidemiology, risk factors, and treatment of severe mental illness in relation to childbirth, focusing on bipolar disorder, affective psychosis, and schizophrenia. We discuss women with ongoing chronic conditions and those with the onset of new episodes of post-partum psychosis. Despite the importance of perinatal episodes, with suicide a leading cause of maternal death, few studies are available to guide the management of women with severe mental disorders in pregnancy and the post-partum period. However, general principles of management are discussed, including the need for an individual risk-benefit analysis for each woman.
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