Journal
LANCET
Volume 380, Issue 9848, Pages 1180-1192Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/S0140-6736(12)61455-X
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Funding
- National Institutes of Health (NIH) [K23 NS060993]
- NINDS [2RO1-44351]
- Clinical and Translational Science Award (CTSA)
- National Center for Research Resources (NCRR) [1UL1RR025011]
- National Center for Advancing Translational Sciences (NCATS) [9U54TR000021]
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Epilepsy is a common neurological disorder that is complicated by psychiatric, cognitive, and social comorbidities that have become a major target of concern and investigation in view of their adverse effect on the course and quality of life. In this report we define the specific psychiatric, cognitive, and social comorbidities of paediatric and adult epilepsy, their epidemiology, and real life effects; examine the relation between epilepsy syndromes and the risk of neurobehavioural comorbidities; address the lifespan effect of epilepsy on brain neurodevelopment and brain ageing and the risk of neurobehavioural comorbidities; consider the overarching effect of broader brain disorders on both epilepsy and neurobehavioural comorbidities; examine directions of causality and the contribution of selected epilepsy-related characteristics; and outline clinic-friendly screening approaches for these problems and recommended pharmacological, behavioural, and educational interventions.
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