Journal
LANCET
Volume 378, Issue 9786, Pages 182-197Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/S0140-6736(11)60207-9
Keywords
-
Categories
Funding
- National Institute for Health Research
- Sanofi-Aventis
- Novo Nordisk UK Research Foundation
- AstraZeneca
- Bristol-Myers Squibb
- GlaxoSmithKline
- Merck Serono
- Merck Sharp Dohme
- Novartis
- Eli Lilly
- Novo Nordisk
- Roche
- Servier
- Takeda
- Boehringer-Ingelheim
- National Institute for Health Research [RTF/01/094] Funding Source: researchfish
Ask authors/readers for more resources
The increasing prevalence, variable pathogenesis, progressive natural history, and complications of type 2 diabetes emphasise the urgent need for new treatment strategies. Longacting (eg, once weekly) agonists of the glucagon-like-peptide-1 receptor are advanced in development, and they improve prandial insulin secretion, reduce excess glucagon production, and promote satiety. Trials of inhibitors of dipeptidyl peptidase 4, which enhance the effect of endogenous incretin hormones, are also nearing completion. Novel approaches to glycaemic regulation include use of inhibitors of the sodium glucose cotransporter 2, which increase renal glucose elimination, and inhibitors of 11 beta-hydroxysteroid dehydrogenase 1, which reduce the glucocorticoid effects in liver and fat. Insulin-releasing glucokinase activators and pancreatic-G-protein-coupled fatty-acid-receptor agonists, glucagon-receptor antagonists, and metabolic inhibitors of hepatic glucose output are being assessed. Early proof of principle has been shown for compounds that enhance and partly mimic insulin action and replicate some effects of bariatric surgery.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available