Journal
PUBLIC HEALTH NUTRITION
Volume 20, Issue 10, Pages 1865-1873Publisher
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S1368980015003092
Keywords
Cholecalciferol; 25-Hydroxyvitamin D; Bangladesh; Developing countries; Infant; Paediatrics; Pregnancy; Nutrition
Funding
- Thrasher Fund (Salt Lake City, UT, USA)
- Department of Paediatrics, The Hospital for Sick Children
- Research and Training Competition (Restracomp), The Hospital for Sick Children Foundation Student Scholarship Program
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Objective: To determine the effect of prenatal maternal vitamin D supplementation on infant vitamin D status in a tropical region where vitamin D supplementation is not routine. Design: A prospective observational follow-up of a randomized trial. Setting: Maternal-child health facility in Dhaka, Bangladesh (23 degrees N). Subjects: Infants born to pregnant women (n 160) randomized to receive 875 mu g (35 000 IU) cholecalciferol (vitamin D3) per week (VD) or placebo (PL) during the third trimester were followed from birth until 6 months of age (n 115). Infant serum 25-hydroxyvitamin D concentration (25(OH) D) was measured at <1, 2, 4 and 6 months of age. Results: Mean infant 25(OH) D was higher in the VD v. PL group at <1 month of age (mean (SD): 80 (20) nmol/l v. 22 (18) nmol/l; P < 0.001), but the difference was attenuated by 2 months (52 (19) nmol/l v. 40 (23) nmol/l; P = 0.05). Groups were similar at 4 months (P = 0.40) and 6 months (n 72; P = 0.26). In the PL group, mean infant 25(OH) D increased to 78 (95 % CI 67, 88) nmol/l by 6 months of age (n 34). 25(OH) D was higher with infant formula-feeding and higher in summer v. winter. Conclusions: Prenatal third-trimester vitamin D supplementation (875 mu g (35000 IU)/week) significantly ameliorated infant vitamin D status during the neonatal period when the risk of vitamin D deficiency is greatest. Further research is warranted to determine factors that contribute to the rise in 25(OH) D during the first 6 months of life among breast-fed infants in this setting.
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