Journal
LABORATORY INVESTIGATION
Volume 89, Issue 6, Pages 614-623Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/labinvest.2009.23
Keywords
caveolae; caveolins; human disease pathogenesis; mouse animal models
Categories
Funding
- NIH/NCI [R01-CA-80250, R01-CA-098779, R01-CA-120876, R01-CA-70896, R01-CA-75503, R01-CA-86072, R01-CA-107382]
- American Heart Association (AHA)
- Muscular Dystrophy Association (MDA)
- American Association for Cancer Research (AACR)
- Susan G. Komen Breast Cancer Foundation
- Department of Defense-Breast Cancer Research Program (Synergistic Idea Award)
- Susan G Komen Breast Cancer Foundation
- WW Smith Charitable Trust
- Breast Cancer Alliance
- Elsa U Pardee Foundation
- NIH/NCI Cancer Center Core [P30-CA-56036]
- Pennsylvania Department of Health
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Here we review the clinical and translational implications of the caveolin gene family for understanding the pathogenesis of human diseases, including breast and prostate cancers, pulmonary hypertension, cardiomyopathy, diabetes, and muscular dystrophy. Detailed phenotypic analysis of caveolin knockout mice has served to highlight the crucial role of a caveolin deficiency in the pathogenesis of many human disease processes. Mutations in the human caveolin genes are associated with a number of established genetic disorders (such as breast cancer, lipodystrophy, muscular dystrophy, and cardiomyopathy), making the caveolins important and novel targets for drug development. The implementation of new strategies for caveolin replacement therapy-including caveolin mimetic peptides-is ongoing. Laboratory Investigation (2009) 89, 614-623; doi:10.1038/labinvest.2009.23; published online 30 March 2009
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