Journal
LAB ON A CHIP
Volume 14, Issue 6, Pages 1060-1073Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3lc51133b
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Funding
- 111 Project
- National Key Scientific Instrument and Equipment Development Program of China [2012YQ030261]
- Xi'An Jiaotong University [DWJXc102000077]
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Intracellular components containing information about genetic and disease characteristics are key substances to clinical diagnostics. Cell lysis is therefore a crucial step for efficient extraction and the subsequent analysis of intracellular components. With the advent of advanced manufacturing techniques, a number of micro systems have been proposed and applied for manipulating cells on chips. In this paper, we review emerging microfluidic devices for cell lysis. Different lysis mechanisms and related techniques are compared. The technical details, advantages, and limitations of various microfluidic devices are discussed.
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