Journal
LAB ON A CHIP
Volume 14, Issue 5, Pages 924-930Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3lc51001h
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Funding
- National Institutes of Health [1DP2OD007209-01]
- American Asthma Foundation (AAF) Scholar Award
- National Science Foundation
- Penn State Center for Nanoscale Science (MRSEC) [DMR-0820404]
- NHLBI Division of Intramural Research
- NSF-funded National Nanotechnology Infrastructure Network
- Div Of Industrial Innovation & Partnersh
- Directorate For Engineering [1346440] Funding Source: National Science Foundation
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Cell enrichment is a powerful tool in a variety of cellular studies, especially in applications with low-abundance cell types. In this work, we developed a standing surface acoustic wave (SSAW) based microfluidic device for non-contact, continuous cell enrichment. With a pair of parallel interdigital transducers (IDT) deposited on a piezoelectric substrate, a one-dimensional SSAW field was established along disposable micro-tubing channels, generating numerous pressure nodes (and thus numerous cell-enrichment regions). Our method is able to concentrate highly diluted blood cells by more than 100 fold with a recovery efficiency of up to 99%. Such highly effective cell enrichment was achieved without using sheath flow. The SSAW-based technique presented here is simple, bio-compatible, label-free, and sheath-flow-free. With these advantages, it could be valuable for many biomedical applications.
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