4.7 Article

Three-dimensional flash flow microreactor for scale-up production of monodisperse PEG-PLGA nanoparticles

Journal

LAB ON A CHIP
Volume 14, Issue 20, Pages 3987-3992

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c4lc00700j

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Funding

  1. National Research Foundation of Korea (NRF) grant - Korea government (MSIP) [2008-0061983]
  2. National Research Foundation of Korea [2008-0061983] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)

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We present a pressure-tolerant 3D parallel polyimide (PI) film microreactor operating at up to similar to 160 bars with direct 3D flow focusing geometry for mass production of PEG-PLGA nanoparticles in a similar to 10(1) gram-scale (g h(-1)).

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