Journal
LAB ON A CHIP
Volume 14, Issue 2, Pages 280-285Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3lc50939g
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Funding
- Department of Energy, Office of Biological and Environmental Research [DE-SC0001249]
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We present a simple microreactor with dimethyl sulfoxide (DMSO) phase-change valves suitable for performing batch organic chemistry under high temperature and pressure conditions. As a proof of principle, we demonstrate a radiofluorination reaction important in the synthesis of [ F-18]FAC, a new positron emission tomography biomarker for immune system monitoring and prediction of chemotherapy response. We achieved high radioactivity recovery (97 +/- 1%, n = 3) and conversion efficiency (83 +/- 1%, n = 3), comparable to that achieved with macroscale systems, but with a volume 30x smaller. This platform overcomes the limitations of previously reported phase-change valves in terms of compatibility with organic chemistry, and extends the range of reaction conditions for carrying out harsh batch chemistry at the microscale.
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