Journal
LAB ON A CHIP
Volume 14, Issue 14, Pages 2418-2427Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4lc00273c
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Funding
- National Natural Science Foundation of China [21136006, 21306117]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT1163]
- National High Technology Research and Development Program [2012AA021403]
- Specialized Research Fund for the Doctoral Program of Higher Education by the Ministry of Education of China [20120181110074]
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Here we report a simple and versatile strategy for the in situ fabrication of nanogel-containing smart membranes in microchannels of microchips. The fabrication approach is demonstrated by the in situ formation of a chitosan membrane containing poly(N-isopropylacrylamide) (PNIPAM) nanogels in a microchannel of a microchip. The PNIPAM nanogels, that allow temperature-and ethanol-responsive swelling-shrinking volume transitions, serve as smart nanovalves for controlling the diffusional permeability of solutes across the membrane. Such self-regulation of the membrane permeability is investigated by using fluorescein isothiocyanate (FITC) as a tracer molecule. This approach provides a promising strategy for the in situ fabrication of versatile nanogel-containing smart membranes within microchips via simply changing the functional nanogels for developing micro-scale detectors, sensors, separators and controlled release systems.
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