Journal
LAB ON A CHIP
Volume 13, Issue 6, Pages 1109-1113Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2lc41169e
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Funding
- European Union through the Europaischer Fonds fur segionale Entwicklung'' EFRE
- Thuringer Ministerium fur Bildung, Wissenschaft und Kultur'' [B714-07037]
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An all-fibre based Raman-on-chip setup is introduced which enables analysis of solutions and trapped particles without microscopes or objectives. Beside the novel quartz microfluidic chip, innovative multi-core single-mode fibres with integrated fibre Bragg gratings are used for detection. The limit of quantitation is 7.5 mM for urea and 2.5 mM for nicotine with linear Raman spectroscopy. This is an improvement of more than two orders of magnitude compared with previous fibre-based microfluidic Raman detection schemes. Furthermore, our device was combined with optical traps to collect Raman-on-chip spectra of spherical polymer beads.
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