Journal
LAB ON A CHIP
Volume 13, Issue 7, Pages 1201-1212Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3lc41017j
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Funding
- National Research Foundation of Korea (NRF) [2012-0003408]
- KFRI (Korea Food Research Institute) [E0121705]
- Hongik University Research Fund
- NIH [R01NS050452, R01EB009429]
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R01EB009429] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS050452] Funding Source: NIH RePORTER
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While in vitro cell based systems have been an invaluable tool in biology, they often suffer from a lack of physiological relevance. The discrepancy between the in vitro and in vivo systems has been a bottleneck in drug development process and biological sciences. The recent progress in microtechnology has enabled manipulation of cellular environment at a physiologically relevant length scale, which has led to the development of novel in vitro organ systems, often termed 'organ-on-a-chip' systems. By mimicking the cellular environment of in vivo tissues, various organ-on-a-chip systems have been reported to reproduce target organ functions better than conventional in vitro model systems. Ultimately, these organ-on-a-chip systems will converge into multi-organ 'body-on-a-chip' systems composed of functional tissues that reproduce the dynamics of the whole-body response. Such microscale in vitro systems will open up new possibilities in medical science and in the pharmaceutical industry.
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