Journal
LAB ON A CHIP
Volume 13, Issue 4, Pages 498-508Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2lc41002h
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Funding
- NSERC-CREATE Training Program in NeuroEngineering
- FRQS doctoral scholarship
- FRQS Chercheur National award
- FRQS Chercheur Junior 1 award
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9Promoting axon regeneration following injury is one of the ultimate challenges of neuroscience, and understanding the mechanisms that regulate axon growth and guidance is essential to achieve this goal. During development axons are directed over relatively long distances by a precise extracellular distribution of chemical signals in the embryonic nervous system. Multiple guidance proteins, including netrins, slits, semaphorins, ephrins and neurotrophins have been identified as key players in this process. During the last decade, engineered cell culture substrates have been developed to investigate the cellular and molecular mechanisms underlying axon guidance. This review is focused on the biological insights that have been achieved using new techniques that attempt to mimic in vitro the spatial patterns of proteins that growth cones encounter in vivo.
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