Journal
LAB ON A CHIP
Volume 13, Issue 14, Pages 2815-2820Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3lc50254f
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Funding
- China Scholarship Council
- Natural Science Foundation of China [20975019, 21235001]
- Fundamental Research Funds for the Central Universities [N110805001, N110705002]
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A microfluidic concentration-gradient droplet array generator (CDrAG) with parallel multi-channels and multi-layers was developed with 64 outlet channels producing 33 droplet gradient concentrations. A droplet production rate of 5 x 6 10(4) min(-1) was obtained, and the RSD value of droplet diameters in 64 groups is 5.5% (n = 64). Using the concentration gradient droplet array as parallel microreactors, 33 Au/Ag ratio nanoparticles were synthesized. The absorption spectra of the Au/Ag nanoparticles shifted from the spectrum of pure gold to one of pure silver. This demonstrates the CDrAG platform's promising potential to produce specific nanoparticle barcodes for high-throughput screening in chemistry, biology and a broad range of life science applications.
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