Journal
LAB ON A CHIP
Volume 13, Issue 5, Pages 940-946Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2lc41049d
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Funding
- Ontario Research Fund
- Canadian Institute for Health Research
- Natural Sciences and Engineering Research Council of Canada
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A rapid, simple and specific cancer cell counting sensor would allow for early detection and better disease management. We have developed a novel cell counting device that can specifically count 125 prostate cancer cells in both complex media with serum and a mixed cell population containing non-target cells within 15 min. The microfabricated glass chip with exposed gold apertures utilizes the anti-EpCAM antibody to selectively count prostate cancer cells via differential pulse voltammetry. The newly developed sensor exhibits excellent sensitivity and selectivity. The cells remain viable throughout the counting process and can be used for further analysis. This device could have utility for future applications in early stage cancer diagnosis.
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