Journal
LAB ON A CHIP
Volume 13, Issue 6, Pages 1070-1078Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2lc41190c
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Funding
- JST-SENTAN, KAKENHI [23106002, 24760204]
- Nagoya University Global COE Program 'COE for Education and Research of Micro-Nano Mechatronics',
- Frontier Research Academy for Young Researchers at Kyushu Institute of Technology
- Grants-in-Aid for Scientific Research [24760204] Funding Source: KAKEN
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In this paper, we propose a novel, magnetically driven microrobot equipped with a frame structure to measure the effects of stimulating aquatic microorganisms. The design and fabrication of the force-sensing structure with a displacement magnification mechanism based on beam deformation are described. The microrobot is composed of a Si-Ni hybrid structure constructed using micro-electro-mechanical system (MEMS) technologies. The microrobots with 5 mu m-wide force sensors are actuated in a microfluidic chip by permanent magnets so that they can locally stimulate the microorganisms with the desired force within the stable environment of the closed microchip. They afford centimetre-order mobility (untethered drive) and millinewton-order forces (high power) as well as force-sensing. Finally, we apply the developed microrobots for the quantitative evaluation of the stimuation of Pleurosira laevis (P. laevis) and determine the relationship between the applied force and the response of a single cell.
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