Journal
LAB ON A CHIP
Volume 13, Issue 7, Pages 1243-1246Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3lc50104c
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We report a proof-of-principle for the use of micro-devices as continuous bioreactors for the production of monoclonal antibodies. We culture CHO cells on the surface of PMMA zigzag'' channels textured with semi-spherical cavities coated with fibronectin, observing steady-state productivities 100 times higher than those observed in full scale systems.
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