Journal
LAB ON A CHIP
Volume 13, Issue 8, Pages 1644-1648Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3lc41415a
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Funding
- NIH [GM096040-01, HL084370-05]
- Institutional Program for Young Researcher Overseas Visits, Japan Society for the Promotion of Science (JSPS)
- National Science Foundation
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We present experiments and theory of a constant flow-driven microfluidic oscillator with widely tunable oscillation periods. This oscillator converts two constant input-flows from a syringe pump into an alternating, periodic output-flow with oscillation periods that can be adjusted to between 0.3 s to 4.1 h by tuning an external membrane capacitor. This capacitor allows multiple adjustable periods at a given input flow-rate, thus providing great flexibility in device operation. Also, we show that a sufficiently large external capacitance, relative to the internal capacitance of the microfluidic valve itself, is a critical requirement for oscillation. These widely tunable microfluidic oscillators are envisioned to be broadly useful for the study of biological rhythms, as on-chip timing sources for microfluidic logic circuits, and other applications that require variation in timed flow switching.
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