Journal
LAB ON A CHIP
Volume 12, Issue 10, Pages 1753-1767Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2lc21273k
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Funding
- Natural Sciences and Engineering Research Council of Canada (NSERC)
- Canada Research Chairs Program
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This article reviews the recent developments in microfluidic technologies for in vitro cancer diagnosis. We summarize the working principles and experimental results of key microfluidic platforms for cancer cell detection, characterization, and separation based on cell-affinity micro-chromatography, magnetic activated micro-sorting, and cellular biophysics (e.g., cell size and mechanical and electrical properties). We examine the advantages and limitations of each technique and discuss future research opportunities for improving device throughput and purity, and for enabling on-chip analysis of captured cancer cells.
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