Journal
LAB ON A CHIP
Volume 12, Issue 12, Pages 2146-2155Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2lc21147e
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Funding
- NSF [DMR-1006546]
- Harvard MRSEC [DMR-0820484]
- Massachusetts Life Sciences Center
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Droplet microfluidics offers significant advantages for performing high-throughput screens and sensitive assays. Droplets allow sample volumes to be significantly reduced, leading to concomitant reductions in cost. Manipulation and measurement at kilohertz speeds enable up to 10(8) samples to be screened in one day. Compartmentalization in droplets increases assay sensitivity by increasing the effective concentration of rare species and decreasing the time required to reach detection thresholds. Droplet microfluidics combines these powerful features to enable currently inaccessible high-throughput screening applications, including single-cell and single-molecule assays.
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