Journal
LAB ON A CHIP
Volume 12, Issue 20, Pages 3991-3994Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2lc40466d
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Funding
- U.S. National Science Foundation [ECCS-1102397]
- Defense Advanced Research Projects Agency (DARPA) N/MEMS S&T Fundamentals Program [N66001-1-4003]
- Div Of Electrical, Commun & Cyber Sys
- Directorate For Engineering [1102397] Funding Source: National Science Foundation
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This report presents a liquid-handling chip capable of executing metering, mixing, incubation, and wash procedures largely under the control of on-board pneumatic circuitry. The only required inputs are four static selection lines to choose between the four machine states, and one additional line for power. State selection is simple: constant application of vacuum to an input causes the device to execute one of its four liquid handling operations. Programmed control of 31 valves, including fast coordinated cycling for peristaltic pumping, is accomplished by pneumatic digital logic circuits built out of microfluidic valves and channels rather than electronics, eliminating the need for the off-chip control machinery that is typically required for integrated microfluidics.
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