Journal
LAB ON A CHIP
Volume 12, Issue 1, Pages 182-189Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1lc20701f
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Funding
- National Science Foundation [EFRI 0938047]
- Virginia Tech Institute for Critical Technology and Applied Science (ICTAS)
- Emerging Frontiers & Multidisciplinary Activities
- Directorate For Engineering [0938047] Funding Source: National Science Foundation
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In this study, the dielectrophoretic response of prostate tumor initiating cells (TICs) was investigated in a microfluidic system utilizing contactless dielectrophoresis (cDEP). The dielectrophoretic response of prostate TICs was observed to be distinctively different than that for non-TICs, enabling them to be sorted using cDEP. Culturing the sorted TICs generated spheroids, indicating that they were indeed initiating cells. This study presents the first marker-free TIC separation from non-TICs utilizing their electrical fingerprints through dielectrophoresis.
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