Journal
LAB ON A CHIP
Volume 12, Issue 16, Pages 2807-2814Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2lc40147a
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Funding
- Research Program through the National Research Foundation of Korea (NRF)
- Ministry of Education, Science and Technology [2010-0027746, 2010-0003589]
- Ajou university research fellowship [S-2010-G0001-00059]
- Advanced Institutes of Convergence Technology (AICT) [2010-P2-10]
- National Research Foundation of Korea [2010-0003589] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Much difficulty has been encountered in manipulating small-scale materials, such as submicron colloidal particles and macromolecules (e.g., DNA and proteins), in microfluidic devices since diffusion processes due to thermal (Brownian) motion become more pronounced with decreasing particle size. Here, we present a novel approach for the continuous focusing of such small-scale materials. First, we successfully focused fluorescent submicron polystyrene (PS) beads along equilibrium positions in microchannels through the addition of a small amount water-soluble polymer [500 ppm poly(ethylene oxide) (PEO)]. Lateral migration velocity significantly depends upon the viscoelastic effect (Weissenberg number: Wi) and the aspect ratio of particle size to channel height (a/h). Interestingly, focusing using viscoelastic flows was also observed for flexible DNA molecules (lambda-DNA and T4-DNA), which have radii of gyration (R-g) of approximately 0.69 mu m and 1.5 mu m, respectively. This small-scale material manipulation using medium viscoelasticity will contribute to the design of nanoparticle separation and genomic mapping devices.
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