Journal
LAB ON A CHIP
Volume 11, Issue 4, Pages 609-619Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0lc00251h
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Funding
- National Heart, Lung, And Blood Institute (NHLBI) [HL084370, HL85156]
- NHLBI Ruth L. Kirschstein NRSA [F30HL095333]
- University of Michigan [NIGMS T32 GM07863]
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL085156, R01HL084370, F30HL095333] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [T32GM007863] Funding Source: NIH RePORTER
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Studies using this micro-system demonstrated significant morphological differences between alveolar epithelial cells (transformed human alveolar epithelial cell line, A549 and primary murine alveolar epithelial cells, AECs) exposed to combination of solid mechanical and surface-tension stresses (cyclic propagation of air-liquid interface and wall stretch) compared to cell populations exposed solely to cyclic stretch. We have also measured significant differences in both cell death and cell detachment rates in cell monolayers experiencing combination of stresses. This research describes new tools for studying the combined effects of fluid mechanical and solid mechanical stress on alveolar cells. It also highlights the role that surface tension forces may play in the development of clinical pathology, especially under conditions of surfactant dysfunction. The results support the need for further research and improved understanding on techniques to reduce and eliminate fluid stresses in clinical settings.
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