Journal
LAB ON A CHIP
Volume 11, Issue 12, Pages 2042-2044Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1lc20231f
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Funding
- NIH [1-DP2-OD002190-01]
- Camille and Henry Dreyfus Foundation
- National Science Foundation
- UIUC
- OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH [DP2OD002190] Funding Source: NIH RePORTER
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We demonstrate a three-step assay on a silicon photonic microring resonator-based detection platform that enables the quantitation of the cardiac biomarker C-reactive protein (CRP) over a dynamic range spanning six orders of magnitude. Using antibody-modified microrings, we sequentially monitor primary CRP binding, secondary recognition of bound CRP by a biotinylated antibody, and tertiary signal amplification using streptavidin-functionalized beads. This detection methodology is applied to CRP quantitation in human serum and plasma samples.
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