Journal
LAB ON A CHIP
Volume 11, Issue 18, Pages 3053-3056Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1lc20365g
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Funding
- National Science Foundation [CBET 1016547, CBET 0967069]
- United States Department of Agriculture [USDA-NRI 2009-35603-05059]
- National Institute of General Medical Sciences [R01GM024417]
- National Institute of Heart, Lung and Blood [R01HL083464]
- National Natural Science Foundation of China [21075070]
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL083464] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM024417] Funding Source: NIH RePORTER
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The network of erythrocyte cytoskeletal proteins significantly influences erythrocyte physical and biological properties. Here we show that the kinetics of erythrocyte lysis during exposure to an electric field is sensitively correlated with defects in the cytoskeletal network. Histograms compiled from single-cell electrical lysis data show characteristics of erythrocyte populations that are deficient in a specific cytoskeletal protein, revealing the presence of cell subpopulations.
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