Journal
LAB ON A CHIP
Volume 11, Issue 19, Pages 3218-3224Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1lc20524b
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Funding
- Natural Sciences and Engineering Research Council (NSERC)
- province of Ontario
- Canada Research Chair (CRC) Program
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Blood samples stored as dried blood spots (DBSs) are emerging as a useful sampling and storage vehicle for a wide range of applications. Unfortunately, the surging popularity of DBS samples has not yet been accompanied by an improvement in automated techniques for extraction and analysis. As a first step towards overcoming this challenge, we have developed a prototype microfluidic system for quantification of amino acids in dried blood spots, in which analytes are extracted, mixed with internal standards, derivatized, and reconstituted for analysis by (off-line and in-line) tandem mass spectrometry. The new method is fast, robust, precise, and most importantly, compatible with automation. We propose that the new method can potentially contribute to a new generation of analytical techniques for quantifying analytes in DBS samples for a wide range of applications.
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