Journal
LAB ON A CHIP
Volume 11, Issue 13, Pages 2262-2267Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0lc00648c
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Funding
- Converging Research Center [2010K001138]
- Happy Tech. Program [2010-0020821]
- MEST [2011-0000311, 2010K001137, 2010-0002229, R32-2010-000-10213-0, 2010-0005574]
- NRF [2011-0000390]
- WCU program [R31-10032]
- System program
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We have developed a method to monitor the activities of human taste receptor protein in lipid membrane using carbon nanotube transistors, enabling a bioelectronic super-taster (BST), a taste sensor with human-tongue-like selectivity. In this work, human bitter taste receptor protein expressed in E. coli was immobilized on a single-walled carbon nanotube field effect transistor (swCNT-FET) with the lipid membrane. Then, the protein binding activity was monitored using the underlying swCNT-FET, leading to the operation as a BST device. The fabricated BST device could detect bitter tastants at 100 fM concentrations and distinguish between bitter and non-bitter tastants with similar chemical structures just like a human tongue. Furthermore, this strategy was utilized to differentiate the responses of taster or non-taster types of the bitter taste receptor proteins.
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