Journal
LAB ON A CHIP
Volume 10, Issue 9, Pages 1199-1203Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b923101c
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Funding
- King Abdullah University of Science and Technology (KAUST) [SA-C0040/UK-C0016]
- Hong Kong RGC [HKUST 603608]
- Nanoscience and Nanotechnology Program at HKUST
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We report a simple methodology to fabricate PDMS multi-layer microfluidic chips. A PDMS slab was surface-treated by trichloro (1H,1H,2H,2H-perfluorooctyl) silane, and acts as a reusable transferring layer. Uniformity of the thickness of the patterned PDMS layer and the well-alignment could be achieved due to the transparency and proper flexibility of this transferring layer. Surface treatment results are confirmed by XPS and contact angle testing, while bonding forces between different layers were measured for better understanding of the transferring process. We have also designed and fabricated a few simple types of 3D PDMS chip, especially one consisting of 6 thin layers (each with thickness of 50 mu m), to demonstrate the potential utilization of this technique. 3D fluorescence images were taken by a confocal microscope to illustrate the spatial characters of essential parts. This fabrication method is confirmed to be fast, simple, repeatable, low cost and possible to be mechanized for mass production.
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