Journal
LAB ON A CHIP
Volume 10, Issue 6, Pages 692-700Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b917743d
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Funding
- NIH [P41 EB002520, R01 HL076485]
- Columbia University Presidential Fellowship
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL076485] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [P41EB002520] Funding Source: NIH RePORTER
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We present a microscale cell culture system with an interdigitated microarray of excimer-laser-ablated indium tin oxide electrodes for electrical stimulation of cultured cells. The system has been characterized in a range of geometeries and stimulation regimes via electrochemical impedance spectroscopy and used to culture primary cardiomyocytes and human adipose derived stem cells. Over 6 days of culture with electrical stimulation (2 ms duration, 1 Hz, 180 mm wide electrodes with 200 mm spacing), both cell types exhibited enhanced proliferation, elongation and alignment, and adipose derived stem cells exhibited higher numbers of Connexin-43-composed gap junctions.
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